Nicotinate → N-hydroxysuccinimide nicotinamide adenine dinucleotide

HRID 376482

반응식

[CH:1]1[CH:6]=[N+:5]([C@@H:7]2[O:11][C@H:10]([CH2:12][O:13][P:14]([O:17][P:18]([O:21][CH2:22][C@H:23]3[O:27][C@@H:26]([N:28]4[C:32]5[N:33]=[CH:34][N:35]=[C:36]([NH2:37])[C:31]=5[N:30]=[CH:29]4)[C@H:25]([OH:38])[C@@H:24]3[OH:39])([OH:20])=[O:19])([O-:16])=[O:15])[C@@H:9]([OH:40])[C@H:8]2[OH:41])[CH:4]=[C:3]([C:42]([NH2:44])=[O:43])[CH:2]=1.C([O-])(=O)C1C=CC=NC=1.C(O)(=O)C1C=CC=NC=1.[OH:63][N:64]1[C:68](=[O:69])[CH2:67][CH2:66][C:65]1=[O:70]>>[OH:63][N:64]1[C:68](=[O:69])[CH2:67][CH2:66][C:65]1=[O:70].[CH:1]1[CH:6]=[N+:5]([C@@H:7]2[O:11][C@H:10]([CH2:12][O:13][P:14]([O:17][P:18]([O:21][CH2:22][C@H:23]3[O:27][C@@H:26]([N:28]4[C:32]5[N:33]=[CH:34][N:35]=[C:36]([NH2:37])[C:31]=5[N:30]=[CH:29]4)[C@H:25]([OH:38])[C@@H:24]3[OH:39])([OH:20])=[O:19])([O-:16])=[O:15])[C@@H:9]([OH:40])[C@H:8]2[OH:41])[CH:4]=[C:3]([C:42]([NH2:44])=[O:43])[CH:2]=1

참가 물질

반응물 3

HCID 937Nicotinate

HCID 5892Nadide

HCID 70268983N-hydroxysuccinimide nicotinate

생성물 1

HCID 131721620N-hydroxysuccinimide nicotinamide adenine dinucleotide

실험 절차

combining nicotinamide adenine dinucleotide with NADase and NHS nicotinate, whereby NADase catalyzes an exchange of N-hydroxysuccinimide nicotinate onto nicotinamide adenine dinucleotide, yielding N-hydroxysuccinimide-nicotinamide adenine dinucleotide; and

출처 및 근거

ORD 기록: ord-82320ba8ddcd4f1ab2c6950cc6228010
출처 데이터셋: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06020480

연결된 노트

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