Sodium Carbonate → 5-(6-Butoxypyridin-3-yl)-2-chloropyrimidine

HRID 376759노트

반응식

HRID 376759 반응식
Br[C:2]1[CH:3]=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH2:9]([O:13][C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][N:15]=1)[CH2:10][CH2:11][CH3:12].C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1.C(O)C.O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH2:9]([O:13][C:14]1[N:15]=[CH:16][C:17]([C:2]2[CH:3]=[N:4][C:5]([Cl:8])=[N:6][CH:7]=2)=[CH:18][CH:19]=1)[CH2:10][CH2:11][CH3:12]

참가 물질

8

반응물 3

HCID 10340Sodium CarbonateHCID 6066655-Bromo-2-chloropyrimidineHCID 45116227(6-Butoxypyridin-3-yl)boronic acid

생성물 1

HCID 193591035-(6-Butoxypyridin-3-yl)-2-chloropyrimidine수율 38%

시약·촉매·용매 4

HCID 178418397HCID 178418397, 화합물촉매HCID 702Ethanol용매HCID 962Water용매HCID 1140Toluene용매

실험 절차

A reaction of 109 mmol of 5-bromo-2-chloropyrimidine, 109 mmol of 2-butoxypyridine-5-boronic acid, 218 mmol of sodium carbonate and 1.1 mmol of tetrakis(triphenylphosphine)palladium(0) in 200 ml of toluene, 100 ml of ethanol and 100 ml of water is carried out analogously to the procedure indicated for precursor 3. Corresponding purification gives 10.8 g (38%) of a colorless solid, m.p. 117° C., cl.p. 130° C.

후처리

  1. custompurification

출처 및 근거

ORD 기록
ord-6f8df8f3641d4a9d8f51d3cac7b0a08c
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06022492

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