Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbamate → 2-Methyl-1-naphthol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbamate | HCID 276 | — |
| 반응물 | 1-Hydroxy-2-naphthoic acid | HCID 6844 | — |
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 2-Methyl-1-naphthol | HCID 24055 | 69.2% |
반응 단계
Minami et al (Chem. Pharm. Bull., 27(3), 816-820, 1979) disclose the following reaction scheme: ethyl chloroformate was added, at a temperature of 0°-5° C. and over a period of 1 hour, to a solution of 1-hydroxy-2-naphthoic acid and triethylamine in tetrahydrofuran whereby the correspondence carbamate was produced. The reaction mixture was added to a solution of sodium borohydride in water, with stirring, at a temperature of 5° to 15° C., and over a period of 1 hour. Extraction with ether gave 2-methyl-1-naphthol in a yield of 69.2%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05420362 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-bfb307b5515741e097ed404e6b01c0f2 |
| 출처 메모 | uspto-grants-1995_05 |