Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → N-diaminomethylene-3-methylsulfonyl-4-(3-pyridyloxy)-6-methylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Carbamimidoylazanium Chloride | HCID 5460839 | — |
| 반응물 | 6-chloro-N-methylpyridinium chloride | HCID 11744962 | — |
| 반응물 | 3-Methylsulfonyl-4-(3-pyridyloxy)-6-methylbenzoic acid | HCID 19360331 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | N-diaminomethylene-3-methylsulfonyl-4-(3-pyridyloxy)-6-methylbenzamide | HCID 10712709 | — |
반응 단계
1.0 g of 3-methylsulfonyl-4-(3-pyridyloxy)-6-methylbenzoic acid [obtainable by reacting 3-methylsulfonyl-4-chloro-6-methylbenzoic acid with 3-hydroxypyridine] is dissolved in 15 ml of 1-methylpyrrolidone, and 0.67 g of 1-methyl-2-chloropyridinium chloride is added to this solution, which is stirred for 15 min. 0.9 g of guanidinium chloride and 2.6 ml of N-ethyldiisopropylamine are then added, and the mixture is stirred at room temperature for one hour. Following customary working-up, N-diaminomethylene-3-methylsulfonyl-4-(3-pyridyloxy)-6-methylbenzamide is obtained, m.p. 221-224°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06022883 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-c2ebe1b38c8f4887a8c02cbc90e35665 |
| 출처 메모 | uspto-grants-2000_02 |