Guanidine → N-(2-chloro-5-trifluoromethylbenzyl)-N-methylaminocarbonylguanidine hydrochloride

반응식

[Cl:1][C:2]1C=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1CNC.C1N=[CH:18][N:17]([C:20]([N:22]2[CH:26]=[N:25][CH:24]=[CH:23]2)=[O:21])C=1.[NH2:27]C(N)=N>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:7][C:8]([C:11]([F:12])([F:14])[F:13])=[CH:9][C:24]=1[CH2:23][N:22]([C:20]([NH:17][CH3:18])=[O:21])[C:26]([NH2:25])=[NH:27]

참가 물질

반응물 3

HCID 3520Guanidine

HCID 682631,1'-Carbonyldiimidazole

HCID 11951932HCID 11951932, 화합물

생성물 1

HCID 19360574N-(2-chloro-5-trifluoromethylbenzyl)-N-methylaminocarbonylguanidine hydrochloride수율 77.7%

실험 절차

1.0 g of N-(2-chloro-5-trifluoromethylbenzyl)-N-methylamine was reacted with 0.75 g of CDI and 1.1 g of guanidine analogously to Example 23. 0.6 g of N-(2-chloro-5-trifluoromethylbenzyl)-N-methylaminocarbonylguanidine hydrochloride is obtained;

출처 및 근거

ORD 기록: ord-758a2f1466fe457496b04e0f8a640eab
출처 데이터셋: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06022899

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