참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Indanone | HCID 6735 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | 2-Bromomethylnaphthalene | HCID 70320 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 6-[(2-Naphthyl)methoxy]-2-methyl-indanone | HCID 19935755 | 697.1% |
반응 단계
A mixture of the indanone (14 g, 86.4 mmole) prepared as described in Example 1, Step D, anhydrous K2CO3 (11.24 g, 81.4 mmole), 18-crown-6 (2.29 g, 6.4 mmole) and 2-bromomethylnaphthalene (11.6 g, 95 mmole) in acetonitrile (275 mL) is heated under nitrogen for 24 hours (in an oil bath set at 70° C.). The acetonitrile is evaporated and the residue is dissolved in water, extracted with ethyl acetate, dried (MgSO4) and evaporated to dryness. The crude product (tan solid) is flash chromatographed (on silica Merck-60, preabsorbed in CH2Cl2, eluted with 8:2 hexane-ethyl acetate) to provide the title compound as a white solid (13.49 g, 52% ).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05420289 |
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| 출처 데이터셋 | uspto-grants-1995_05 |
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| ORD ID | ord-46a992045757439585144887b9465636 |
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| 출처 메모 | uspto-grants-1995_05 |
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