Ethyl-1-propyl-1,3,4,9-tetrahydro-6-(phenylmethoxy)pyrano[3,4-b]indole-1-acetate → Ethyl-1-propyl-1,3,4,9-tetrahydro-6-hydroxypyrano[3,4-b]indole-1-acetate

HRID 37702

반응식

HRID 37702 반응식
[CH2:1]([O:3][C:4](=[O:30])[CH2:5][C:6]1([CH2:27][CH2:28][CH3:29])[C:11]2[NH:12][C:13]3[C:18]([C:10]=2[CH2:9][CH2:8][O:7]1)=[CH:17][C:16]([O:19]CC1C=CC=CC=1)=[CH:15][CH:14]=3)[CH3:2]>[Pd].C(O)C>[CH2:1]([O:3][C:4](=[O:30])[CH2:5][C:6]1([CH2:27][CH2:28][CH3:29])[C:11]2[NH:12][C:13]3[C:18]([C:10]=2[CH2:9][CH2:8][O:7]1)=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)[CH3:2]

참가 물질

4

반응물 1

HCID 19935728Ethyl-1-propyl-1,3,4,9-tetrahydro-6-(phenylmethoxy)pyrano[3,4-b]indole-1-acetate

생성물 1

HCID 19935742Ethyl-1-propyl-1,3,4,9-tetrahydro-6-hydroxypyrano[3,4-b]indole-1-acetate수율 89.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A suspension of the 6-benzyloxypyranoindole (5.4 g, 13.25 mmol) of Step A, and 10% Pd/C catalyst (600 mg) in ethanol (150 mL) is hydrogenated for 6 hours in a Parr shaker. Filtration of the catalyst and evaporation of the solvent affords the title compound (3.75 g, 89%) as a cream-colored foam homogeneous by TLC.

후처리

  1. filtrationFiltration of the catalyst and evaporation of the solvent

출처 및 근거

ORD 기록
ord-85a7e5c46b2c42ea8680c7c2812bb776
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420289

연결된 노트

불러오는 중…