Formaldehyde → 3-(3-Bromo-4-chlorophenyl)thiazolidin-4-one

HRID 377021노트

반응식

HRID 377021 반응식
[C:1]([OH:5])(=O)[CH2:2][SH:3].[CH2:6]=O.[Br:8][C:9]1[CH:10]=[C:11]([CH:13]=[CH:14][C:15]=1[Cl:16])[NH2:12]>C1(C)C=CC=CC=1>[Br:8][C:9]1[CH:10]=[C:11]([N:12]2[C:1](=[O:5])[CH2:2][S:3][CH2:6]2)[CH:13]=[CH:14][C:15]=1[Cl:16]

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 1133Thioglycolic AcidHCID 128437223-Bromo-4-chloroaniline

생성물 1

HCID 193607783-(3-Bromo-4-chlorophenyl)thiazolidin-4-one

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Thioglycolic acid (8.65 g) and 37% aqueous formaldehyde (4.6 ml) was added to a stirred solution of 3-bromo-4-chloroaniline (9.73 g) in toluene (50 ml). The mixture was heated to reflux and the water collected in a Dean and Stark apparatus. After 3 hours the mixture was cooled, diluted with toluene then washed with aqueous sodium hydroxide and water. The organic layer was dried (MgSO4) and concentrated to give the subtitle compound as a solid.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. customthe water collected in a Dean and Stark apparatus
  4. temperatureAfter 3 hours the mixture was cooled
  5. additiondiluted with toluene
  6. washthen washed with aqueous sodium hydroxide and water
  7. dry with materialThe organic layer was dried (MgSO4)
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-55f5dd449ef5494aac677a1f07786f7f
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06022976

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