Water → 2-Cyclopropylethyl methanesulfonate

HRID 377031

반응식

HRID 377031 반응식
[CH:1]1([CH2:4][CH2:5][OH:6])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16].O>ClCCl>[CH3:14][S:15]([O:6][CH2:5][CH2:4][CH:1]1[CH2:3][CH2:2]1)(=[O:17])=[O:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 1376422-Cyclopropylethan-1-ol

생성물 1

HCID 145578092-Cyclopropylethyl methanesulfonate수율 99.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 2-cyclopropylethanol (2.1 g, 24.4 mmol) in dichloromethane (50 ml) at 0° C. under nitrogen was added triethylamine (4.1 ml, 1.3 mol equiv). Methanesulphonyl chloride (2.5 ml, 1.3 mol equiv) was added dropwise and the reaction stirred for 16 hours at room temperature. Water (30 ml) and dichloromethane (30 ml) were added. The organic phase was washed with water (2×50 ml) and then dried over anhydrous MgSO4. The solution was then filtered and the solvent removed in vacuo to give the title compound as an oil (4.0 g).

후처리

  1. washThe organic phase was washed with water (2×50 ml)
  2. dry with materialdried over anhydrous MgSO4
  3. filtrationThe solution was then filtered
  4. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-a4311a0b0e1b4e95834ba5370e1644a0
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06022971

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