Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(4-Chloro-2-methyl-phenoxy)-3-methyl-5-nitropyridine → 2-(4-Chloro-2-methyl-phenoxy)-3-methyl-5-amino-pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(4-Chloro-2-methyl-phenoxy)-3-methyl-5-nitropyridine | HCID 18419461 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(4-Chloro-2-methyl-phenoxy)-3-methyl-5-amino-pyridine | HCID 15887616 | — |
반응 단계
2- (4-chloro-2-methyl-phenoxy) -3-methyl-5-nitropyridine (5.8 g, 20.8 mmol) was dissolved in 95% ethanol (50 mL) and treated with 20% palladium hydroxide on carbon (350 mg). The reaction mixture was shaken in a hydrogen atmosphere (40 psi) for 1 hour. The solution was filtered through celite and concentrated in vacuo followed by chromatography on SiO2 using 1:1 ethyl acetate/hexanes as eluant. MS (m/z): 248/250 (M+H)+ ; C13H13N2OCl requires 248.7.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06022884 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-28a4d5393c8e4226b3b0cf1e9d761342 |
| 출처 메모 | uspto-grants-2000_02 |