Potassium Carbonate → 2-(1,2-Epoxycyclohexyl)-4,5-diphenyloxazole

HRID 377313노트

반응식

HRID 377313 반응식
Br[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1([C:9]1[O:10][C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:13]=1)[OH:8].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:8]1[CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]12[C:9]1[O:10][C:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:13]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 193585162-Bromo-1-(4,5-diphenyl-2-oxazolyl)cyclohexanol

생성물 1

HCID 184591642-(1,2-Epoxycyclohexyl)-4,5-diphenyloxazole수율 98.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2-bromo-1-(4,5-diphenyl-2-oxazolyl)-cyclohexanol (120 mg) and potassium carbonate (83 mg) in N,N-dimethylformamide (0.3 ml) was stirred at room temperature for 6 hours and partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over magnesium sulfate, and evaporated in vacuo to afford 2-(1,2-epoxycyclohexyl)-4,5-diphenyloxazole (94 mg) as a pale yellow powder.

후처리

  1. custompartitioned between ethyl acetate and water
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-6f715285732440fca41c8f5f3e33e817
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06025375

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