Water ethanol → (2Z,4E)-5-(5-Chlorobenzofuran-2-yl)-2-methoxy-2,4-pentadienoic acid

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](/[CH:10]=[CH:11]/[CH:12]=[C:13](\[O:18][CH3:19])/[C:14]([O:16]C)=[O:15])=[CH:7][C:6]=2[CH:20]=1.CCO.O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](/[CH:10]=[CH:11]/[CH:12]=[C:13](\[O:18][CH3:19])/[C:14]([OH:16])=[O:15])=[CH:7][C:6]=2[CH:20]=1

참가 물질

반응물 2

HCID 19096565Water ethanol

HCID 86755125HCID 86755125, 화합물

생성물 1

HCID 19358675(2Z,4E)-5-(5-Chlorobenzofuran-2-yl)-2-methoxy-2,4-pentadienoic acid수율 65.4%

실험 절차

To a stirred solution of methyl (2Z,4E)-5-(5-chlorobenzofuran-2-yl)-2-methoxy-2,4-pentadienoate (530 mg, 1.81 mmol) in EtOH/water 1/1 (40 ml) potassium hydroxide (0.43 g, 7.66 mmol) was added. The solution was stirred at RT overnight, then it was treated as seen in example 2. Pure title compound (330 mg, 1.18 mmol, yield 65.4%) was obtained as bright yellow crystals.

후처리

additionit was treated

출처 및 근거

ORD 기록: ord-8741bc70ae044fa29754305e64247e5d
출처 데이터셋: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06025390

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