(Triphenylphosphoranylidene)acetaldehyde → (E)-3-(3-Methylbenzothiophen-2-yl)-2-propenal
반응식
[CH3:1][C:2]1[C:3]2[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=2[S:5][C:6]=1[CH:7]=O.[CH:13]([CH:15]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:14]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[C:3]2[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=2[S:5][C:6]=1/[CH:7]=[CH:15]/[CH:13]=[O:14]참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
3-Methylbenzo[b]thiophene-2-carboxaldehyde (4.2 g, 23.8 mmol) was dissolved in dry toluene (100 ml) and treated with (formylmethylene)triphenylphosphorane (7.35 g, 24.2 mmol). The reaction mixture was heated to 80° C. for 10 hours, allowed to cool and the residue was washed with 200 ml of hexane/Et2O 1/1 and then triturated with isopropyl ether to give pure title compound (2.5 g, 12.38 mmol, yield 52.0%), m.p.=90-92+ C.
후처리
- temperatureto cool
- washthe residue was washed with 200 ml of hexane/Et2O 1/1
- customtriturated with isopropyl ether
출처 및 근거
- ORD 기록
- ord-e24a02f6268443a78b230af36e4eaaed
- 출처 데이터셋
- uspto-grants-2000_02
- 특허 번호
- US06025390
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