4-Toluenesulfonyl chloride → 1-(2-Chloroethyl)piperidine

HRID 377421

반응식

HRID 377421 반응식
C1(C)C=CC(S([Cl:10])(=O)=O)=CC=1.[N:12]1([CH:18](O)[CH3:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C(Cl)Cl>[Cl:10][CH2:19][CH2:18][N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 30305411-(Piperidin-1-yl)ethanol

생성물 1

HCID 748271-(2-Chloroethyl)piperidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Into a 50 mL round bottom flask is placed 6.40 g (33.6 mmol) of p-toluenesulfonyl chloride and 25 mL of methylene chloride. The resulting solution is cooled with an ice bath as 4.00 g (31.0 mmol) of 1-piperidinoethanol in 6 mL of methylene chloride is added dropwise. After the addition is complete, the ice bath is removed and the resulting slurry is stirred for about 12 hours. The reaction mixture is concentrated on a rotary evaporator to yield a solid residue which may then be used as in Preparation 4 below.

후처리

  1. customInto a 50 mL round bottom flask is placed
  2. additionis added dropwise
  3. additionAfter the addition
  4. customthe ice bath is removed
  5. concentrationThe reaction mixture is concentrated on a rotary evaporator
  6. customto yield a solid residue which
  7. custommay then be used as in Preparation 4 below

출처 및 근거

ORD 기록
ord-272121b4d9e74189a3251e5a42e2b264
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06025495

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