HCID 66916713, 화합물 → HCID 66916737, 화합물

HRID 37744노트

반응식

HRID 37744 반응식
C([O:5][C:6](=[O:33])[CH2:7][N:8]([S:17]([C:20]1[CH:25]=[CH:24][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:9][C:10]([O:12]C(C)(C)C)=[O:11])(C)(C)C>C(O)=O>[O:26]([C:23]1[CH:22]=[CH:21][C:20]([S:17]([N:8]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][C:6]([OH:33])=[O:5])(=[O:19])=[O:18])=[CH:25][CH:24]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

참가 물질

3

반응물 1

HCID 66916713HCID 66916713, 화합물

생성물 1

HCID 66916737HCID 66916737, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

Compound 4a (1.02 g, 2.14 mmol) was dissolved in formic acid (10 mL) and stirred overnight at room temperature. The solid was filtered off, the filtrate was evaporated in vacuo, and co-evaporated with toluene (6×20 mL). The pure product obtained was dried overnight in high vacuum. Yield: 0.71 g, 1.95 mmol, 91% (off-white solid). 1H-NMR (DMSO-d6): δ 7.91 (d, 2H, 3JHH=9.0 Hz, ArH), 7.20 (d, 2H, 3JHH=9.0 Hz, ArH), 7.28 (d, 2H, 3JHH=9.0 Hz, ArH), 7.00 (d, 1H, 3JHH=9.0 Hz, ArH), 6.87 (d, 2H, 3JHH=9.0 Hz, ArH), 4.07 (s, 4H, 2×CH2CO2H).

후처리

  1. filtrationThe solid was filtered off
  2. customthe filtrate was evaporated in vacuo
  3. customThe pure product obtained
  4. customwas dried overnight in high vacuum

출처 및 근거

ORD 기록
ord-a06dae072eb2430396e7a4c03ad82404
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524194B2

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