Water → 7-(3-Bromopropoxy)-3-piperidino-2,2-dimethylbenzofuran

HRID 3775

반응식

HRID 3775 반응식
[OH-].[K+].O.[OH:4][C:5]1[C:13]2[O:12][C:11]([CH3:15])([CH3:14])[CH:10]([N:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[C:9]=2[CH:8]=[CH:7][CH:6]=1.[Br:22][CH2:23][CH2:24][CH2:25]Br>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.C(OCC)C>[Br:22][CH2:23][CH2:24][CH2:25][O:4][C:5]1[C:13]2[O:12][C:11]([CH3:14])([CH3:15])[CH:10]([N:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[C:9]=2[CH:8]=[CH:7][CH:6]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 80011,3-DibromopropaneHCID 14797Potassium HydroxideHCID 141266507-Hydroxy-3-piperidino-2,2-dimethylbenzofuran

생성물 1

HCID 141266517-(3-Bromopropoxy)-3-piperidino-2,2-dimethylbenzofuran

시약·촉매·용매 2

HCID 70681Tetrabutylammonium Chloride촉매HCID 3283Diethyl Ether용매2회

실험 절차

Potassium hydroxide (1.47 g), tetrabutyl ammonium chloride (0.77 g) and H2O (1 ml) are added to a solution of the product obtained in Step 6. (6.6 g) in 1,3-dibromopropane (27 ml). The reaction mixture is stirred for 20 hours and diluted with diethyl ether and washed with 5% aq. HCl. The acidic solution is washed with ether and basified, affording an oil which is taken up in ether, washed with sat'd NaCl, dried, filtered and evaporated in vacuo affording the desired product as an oil.

후처리

  1. washwashed with 5% aq. HCl
  2. washThe acidic solution is washed with ether
  3. custombasified, affording an oil which
  4. washwashed with sat'd NaCl
  5. customdried
  6. filtrationfiltered
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-f0acfd39ea7a462683b5b3c43269d05e
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722925

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