참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-chloro-N,N-dimethyl-5-nitropyrimidin-4-amine | HCID 7113622 | — |
반응 단계
Dissolve 50 g (0.26 mol) of 4,6-dichloro-5-nitropyrimidine in 500 mL of CH2Cl2 and cool to -70° C. Add a solution of 24 mL (0.28 mol) dimethylamine, 70 mL (0.40 mol) of diisopropylethylamine, and 100 mL of CH2Cl2 over 30 minutes. Warm to ambient temperature and wash the reaction mixture with 500 mL of 20% K2CO3. Dry the CH2Cl2 portion over MgSO4, treat with charcoal filter, and remove the filtrate under vacuum. Crystallize the residue with ether to provide 4-dimethylamino-6-chloro-5-nitropyrimidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06025489 |
|---|
| 출처 데이터셋 | uspto-grants-2000_02 |
|---|
| ORD ID | ord-ce50dedc3d6a49e4ad3462d40aaac1ad |
|---|
| 출처 메모 | uspto-grants-2000_02 |
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