Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 9-(1H-imidazol-1-yl)methyl-4-[(2-phenylethyl)amino]imidazo[5,1-h]pteridin-6(5H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | N-Benzylphenethylamine | HCID 65055 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 2-(1H-imidazol-1-ylmethyl)-1H-imidazole | HCID 19358846 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | 9-(1H-imidazol-1-yl)methyl-4-[(2-phenylethyl)amino]imidazo[5,1-h]pteridin-6(5H)-one | HCID 9908192 | — |
반응 단계
Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N-benzylphenethylamine, followed by reaction with 2-((1H-imidazol-1-yl)methyl)imidazole, reduction with tin (II) chloride, cyclization with carbonyidiimidazole and hydrogenation with palladium on carbon in ethanol containing 1.1 eq. NaOH at 50° C. and 50 psi.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06025489 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-c05bad6c92b345d388ba0759b01712cc |
| 출처 메모 | uspto-grants-2000_02 |