Methanol → Methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylate

HRID 377636노트

반응식

HRID 377636 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21]([OH:23])=[O:22])[C:9]=2[CH3:24])=[CH:4][CH:3]=1.[CH3:25]O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21]([O:23][CH3:25])=[O:22])[C:9]=2[CH3:24])=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 887MethanolHCID 15194215-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

생성물 1

HCID 19356244Methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylate

실험 절차

19.54 g of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid are dissolved in 350 ml of MeOH, 0.97 g of paratoluenesulfonic acid is added and the mixture is then refluxed for 18 hours. After evaporation of the solvent, the residue is taken up with AcOEt and washed with saturated NaHCO3 solution and then with saturated NaCl solution. It is dried over MgSO4, the insoluble material is filtered off and the filtrate is then concentrated to dryness to give 18.53 g of the expected compound, m.p.=133° C.

후처리

  1. temperaturethe mixture is then refluxed for 18 hours
  2. customAfter evaporation of the solvent
  3. washwashed with saturated NaHCO3 solution
  4. dry with materialIt is dried over MgSO4
  5. filtrationthe insoluble material is filtered off
  6. concentrationthe filtrate is then concentrated to dryness

출처 및 근거

ORD 기록
ord-5d15404827ee44daa2120a4c7c345c9c
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028084

반응 노트

불러오는 중…