Triethylamine → 3-(4-Trifluoromethylbenzamido)propan-1-ol

HRID 377724

반응식

HRID 377724 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1>ClCCl>[F:13][C:14]([F:24])([F:25])[C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:1][CH2:2][CH2:3][CH2:4][OH:5])=[O:20])=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 90863-Amino-1-propanolHCID 676074-(Trifluoromethyl)benzoyl chloride

생성물 1

HCID 220068303-(4-Trifluoromethylbenzamido)propan-1-ol수율 85%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A reaction vessel was charged with 7.51 g of 3-amino-1-propanol, 2.53 g of triethylamine and 50 ml of dichloromethane, and 5.21 g of 4-trifluoromethylbenzoyl chloride was slowly added dropwise under ice cooling. After stirring at room temperature for 6 hours, the reaction mixture was successively washed with diluted hydrochloric acid and water, dried over anhydrous magnesium sulfate, and then concentrated, which afforded 5.25 g of 3-(4-trifluoromethylbenzamido)propan-1-ol (85% yield).

후처리

  1. additionwas slowly added dropwise under ice cooling
  2. washthe reaction mixture was successively washed with diluted hydrochloric acid and water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-67b8943e2bab437695ddc76cdbffb0e8
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028100

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