CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid
반응식
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1참가 물질
4
실험 절차
5% Pd/C (11.0 g) is added to p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.6 l ethanol. The mixture is hydrogenated at room temperature at 40 p.s.i. When the hydrogen uptake ceases, the catalyst is filtered off, and the filtrate is concentrated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which is used without weighing in the next step.
후처리
- customis hydrogenated at room temperature at 40 p.s.i
- filtrationWhen the hydrogen uptake ceases, the catalyst is filtered off
- concentrationthe filtrate is concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-a801ed2c651849f5bf6530bfe49a45db
- 출처 데이터셋
- uspto-grants-2000_02
- 특허 번호
- US06028116
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