CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid

HRID 377740

반응식

HRID 377740 반응식
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1

참가 물질

4

반응물 1

HCID 367964CID 367964

생성물 1

HCID 154877913-(4-Fluorophenyl)-2-methylpropanoic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

5% Pd/C (11.0 g) is added to p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.6 l ethanol. The mixture is hydrogenated at room temperature at 40 p.s.i. When the hydrogen uptake ceases, the catalyst is filtered off, and the filtrate is concentrated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which is used without weighing in the next step.

후처리

  1. customis hydrogenated at room temperature at 40 p.s.i
  2. filtrationWhen the hydrogen uptake ceases, the catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-a801ed2c651849f5bf6530bfe49a45db
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028116

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