Oxalyl chloride → (Z)-5-Fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indenylacetyl chloride

HRID 377742노트

반응식

HRID 377742 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)/[C:6]([CH3:20])=[C:5]2[CH2:21][C:22]([OH:24])=O.C(Cl)(=O)C([Cl:28])=O>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)/[C:6]([CH3:20])=[C:5]2[CH2:21][C:22]([Cl:28])=[O:24]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 5352624Sulindac Sulfide

생성물 1

HCID 88255253(Z)-5-Fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indenylacetyl chloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(Z)-5-fluoro-2-methyl-1-(4-methythiobenzylidene)-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 35 ml) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.

후처리

  1. customThe solvent is evaporated

출처 및 근거

ORD 기록
ord-7e99e7b5e37b4901afa446cb2498d348
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028116

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