Oxalyl chloride → (Z)-5-Methoxy-2-methyl-1-(4-methylsulfonylbenzylidene)-3-indenylacetyl chloride

HRID 377762노트

반응식

HRID 377762 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)/[C:8](=[CH:12]\[C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1)/[C:7]([CH3:23])=[C:6]2[CH2:24][C:25]([OH:27])=O.C(Cl)(=O)C([Cl:31])=O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)/[C:8](=[CH:12]\[C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1)/[C:7]([CH3:23])=[C:6]2[CH2:24][C:25]([Cl:31])=[O:27]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 70286603(Z)-5-methoxy-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenylacetic acid

생성물 1

HCID 86755164(Z)-5-Methoxy-2-methyl-1-(4-methylsulfonylbenzylidene)-3-indenylacetyl chloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(Z)-5-methoxy-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 35 ml) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.

후처리

  1. customThe solvent is evaporated

출처 및 근거

ORD 기록
ord-f3ec563f032d4b35836b0afa092cb643
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028116

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