Sodium Cyanide → 1'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile

HRID 377795

반응식

HRID 377795 반응식
[C-:1]#[N:2].[Na+].[CH2:4]([N:11]1[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>O.CO>[CH2:4]([N:11]1[CH2:16][CH2:15][C:14]([C:1]#[N:2])([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:13][CH2:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

6

반응물 3

HCID 8929Sodium CyanideHCID 192201-Benzyl-4-piperidoneHCID 2723721Piperidine, hydrochloride (1:1)

생성물 1

HCID 27334341'-(Phenylmethyl)-(1,4'-bipiperidine)-4'-carbonitrile수율 95.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

A solution of 5.3 g of sodium cyanide in 20 ml of water is added dropwise at RT to a solution of 18.9 g of 1-benzylpiperid-4-one and 12.16 g of piperidine hydrochloride in 25 ml of MeOH and 25 ml of water and the mixture is stirred for 48 hours at RT. The precipitate formed is filtered off, washed with water and dried under vacuum to give 27 g of the expected product.

후처리

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-46985320c2c84f1589a55e8d4035f440
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028082

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