Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide

HRID 377796노트

반응식

HRID 377796 반응식
[Br:1]Br.Cl.[C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:6])[CH3:5].CCOCC>C(Cl)Cl>[BrH:1].[Br:1][CH2:5][C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)=[O:6]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 27237674-Acetyl-4-phenylpiperidine hydrochloride

생성물 1

HCID 227417564-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide수율 196.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

8 g of bromine are added rapidly at RT to a suspension of 11.98 g of 4-acetyl-4-phenylpiperidine hydrochloride in 200 ml of DCM and the reaction mixture is left to stand overnight at RT, with stirring. It is diluted by the addition of 200 ml of ether and the precipitate formed is filtered off and washed with ether to give 17.88 g of the expected product after drying under vacuum.

후처리

  1. waitthe reaction mixture is left
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washwashed with ether

출처 및 근거

ORD 기록
ord-77910072d5194837bd00c3a744324e53
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028082

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