Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]perhydroazepine hydrochloride hemihydrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Phenyl-4-(pyrrolidin-1-ylcarbonyl)piperidine | HCID 3019485 | — |
| 반응물 | 1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-(methanesulfonyloxy)propyl]-perhydroazepine | HCID 21702966 | — |
| 용매 | acetonitrile N,N-dimethylformamide | HCID 21891449 | — |
| 생성물 | 1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-phenyl-4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]perhydroazepine hydrochloride hemihydrate | HCID 131721657 | 31.7% |
반응 단계
This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.96 g of 4-phenyl-4-(pyrrolidin-1-ylcarbonyl)-piperidine, 1.5 g of the compound obtained in step C of EXAMPLE 13 and 1.5 g of K2CO3 in 10 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.34 g of the expected product, m.p.=135° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06028082 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-bb7f54aa765e4de4b72d387073878a58 |
| 출처 메모 | uspto-grants-2000_02 |