Trifluoroacetic acid → 1-Methoxy-4,5-dimethyl-2-nitrobenzene

HRID 377915

반응식

HRID 377915 반응식
FC(F)(F)C(O)=O.[CH3:8][C:9]1[CH:10]=[C:11]([O:16][CH3:17])[CH:12]=[CH:13][C:14]=1[CH3:15].[N:18]([O-:20])=[O:19].[Na+]>O>[CH3:15][C:14]1[C:9]([CH3:8])=[CH:10][C:11]([O:16][CH3:17])=[C:12]([N+:18]([O-:20])=[O:19])[CH:13]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 784113,4-DimethylanisoleHCID 23668193Sodium Nitrite

생성물 1

HCID 193571651-Methoxy-4,5-dimethyl-2-nitrobenzene수율 55%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Trifluoroacetic acid(250 ml) was added into 3,4-dimethylanisole(17.1 g, 0.13 mol), successively sodium nitrite(16.6 g, 0.24 mol) was added slowly in water bath, and stirred at room temperature for 14 hrs. After trifluoroacetic acid was removed and water was added thereto, the resulting mixture was extracted with ether, and purified by column chromatography to obtain the titled compound.

후처리

  1. customAfter trifluoroacetic acid was removed
  2. additionwater was added
  3. extractionthe resulting mixture was extracted with ether
  4. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-65c7820380f148e6823b876dab1e3971
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028195

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