Tetrahydrofuran → 2-Methoxy-4,5-dimethylaniline

HRID 377916노트

반응식

HRID 377916 반응식
O1CCCC1.[CH3:6][C:7]1[C:12]([CH3:13])=[CH:11][C:10]([O:14][CH3:15])=[C:9]([N+:16]([O-])=O)[CH:8]=1>[Pd].C(O)C>[CH3:13][C:12]1[C:7]([CH3:6])=[CH:8][C:9]([NH2:16])=[C:10]([O:14][CH3:15])[CH:11]=1

참가 물질

5

반응물 2

HCID 8028TetrahydrofuranHCID 193571651-Methoxy-4,5-dimethyl-2-nitrobenzene

생성물 1

HCID 193571402-Methoxy-4,5-dimethylaniline수율 82%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Tetrahydrofuran(100 ml) and ethanol(40 ml) were added into 4,5-dimethyl-2-nitroanisole(7.80 g, 0.043 mol) and then added 10% Pd/activated carbon(0.57 g) slowly, hydrogenated for 5 hrs. The reaction was completed by the same way with the above and the resulting product was purified by column chromatography to obtain the titled compound.

후처리

  1. customwas purified by column chromatography

출처 및 근거

ORD 기록
ord-4c9f20c9fc284dd990bb3a0f2b887d33
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028195

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