Dichloromethane → Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate

HRID 377917노트

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HRID 377917 반응식
[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][C:5]([NH2:6])=[C:4]([O:10][CH3:11])[CH:3]=1.C(Cl)Cl.Cl[C:16]([O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:17]>O>[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][C:5]([NH:6][C:16](=[O:17])[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[C:4]([O:10][CH3:11])[CH:3]=1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 15891Phenyl chloroformateHCID 193571402-Methoxy-4,5-dimethylaniline

생성물 1

HCID 19357180Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate수율 98%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 4,5-dimethyl-2-methoxyaniline(4.50 g, 0.03 mol), methylene chloride(100 ml) was added and phenyl chloroformate(4.80 g, 0.03 mol) was added slowly. The resulting solution was stirred for 2 hrs and thereto water(150 ml) was added, and extracted with methylene chloride and purified by column chromatography to obtain the titled compound.

후처리

  1. extractionextracted with methylene chloride
  2. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-9aaedd679882450eacbdbdc42be67a34
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028195

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