o-(1-Piperazinyl)phenol → 1-[(4,5-Dimethyl-2-methoxyphenyl)aminocarbonyl]-4-(2-hydroxyphenyl)piperazine

HRID 377919노트

반응식

HRID 377919 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)=[C:4]([O:19][CH3:20])[CH:3]=1.[OH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([NH:9][C:10]([N:31]2[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[OH:21])[CH2:33][CH2:32]2)=[O:18])=[C:4]([O:19][CH3:20])[CH:3]=1

참가 물질

3

반응물 2

HCID 70530o-(1-Piperazinyl)phenolHCID 19357180Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate

생성물 1

HCID 193570401-[(4,5-Dimethyl-2-methoxyphenyl)aminocarbonyl]-4-(2-hydroxyphenyl)piperazine수율 87%

실험 절차

Phenyl N-(4,5-dimethyl-2-methoxyphenyl)carbamate and 1-(2-hydroxyphenyl)piperazine were reacted by the same way with the example 170 to obtain the titled compound.

출처 및 근거

ORD 기록
ord-730f1c56b66a4a808de680763cf17488
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028195

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