Dichloromethane → Phenyl N-(4,5-dimethyl-2-methoxyphenyl)thiocarbamate

HRID 377924노트

반응식

HRID 377924 반응식
C[C:2]1[C:3]([O:10][CH3:11])=[C:4]([CH:6]=[CH:7][C:8]=1[CH3:9])[NH2:5].[CH2:12](Cl)Cl.[CH:15]1[CH:20]=[CH:19][C:18]([O:21][C:22](Cl)=[S:23])=[CH:17][CH:16]=1>O>[CH3:9][C:8]1[C:7]([CH3:12])=[CH:6][C:4]([NH:5][C:22](=[S:23])[O:21][C:18]2[CH:19]=[CH:20][CH:15]=[CH:16][CH:17]=2)=[C:3]([O:10][CH3:11])[CH:2]=1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 70498Phenyl thioxochloroformateHCID 178964772-Methoxy-3,4-dimethylaniline

생성물 1

HCID 53857756Phenyl N-(4,5-dimethyl-2-methoxyphenyl)thiocarbamate수율 92%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 3,4-dimethyl-2-methoxyaniline(4.50 g, 0.03 mol), methylene chloride(100 ml) was added and then phenyl chlorothionoformate(5.16 g, 0.03 mol) was added slowly. The resulting mixture was stirred for 2 hours, and thereto water(150 ml) was added. The resulting mixture was extracted with methylene chloride and purified by column chromatography to obtain the titled compound.

후처리

  1. extractionThe resulting mixture was extracted with methylene chloride
  2. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-4ed0aabd626a4eeeb2ae2dba8c03d4fc
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06028195

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