Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Thiophenecarboxaldehyde → Methyl 3-amino-3-(2-thienyl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| 반응물 | 3-Amino-3-(thiophen-2-yl)propanoic acid | HCID 249306 | — |
| 반응물 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 반응물 | Acetonitrile ether | HCID 21885917 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 3-amino-3-(2-thienyl)propanoate | HCID 2764295 | — |
반응 단계
A solution of 3-amino-3-(2-thienyl)propanoic acid (0.5 g) [prepared substituting a molar equivalent amount of 2-thiophene-carboxaldehyde in Example 57, Step A] in methanol (50 ml) was treated with 4N HCl/dioxane (10 ml). After 6 hours the excess solvent was removed under reduced pressure to give a waxy solid. Treatment with Et2O/CH3CN produced methyl β-aminothiophene-2-propanoate (370 mg) as a white powder. MS and 1H-NMR were consistent with the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06028223 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-2d23fc5e8f0b4601948e7527f629a05a |
| 출처 메모 | uspto-grants-2000_02 |