Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methylpyridine → 2-Methyl-1-[2-oxo-2-(tetrahydro-pyran-4-yl)-ethyl]-pyridinium bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methylpyridine | HCID 7975 | — |
| 반응물 | 2-Bromo-1-(oxan-4-yl)ethan-1-one | HCID 13197225 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Methyl-1-[2-oxo-2-(tetrahydro-pyran-4-yl)-ethyl]-pyridinium bromide | HCID 86649690 | 86.4% |
반응 단계
A mixture of 2-bromo-1-(tetrahydro-pyran-4-yl)-ethanone (0.6 g, 2.89 mmol) and 2-picoline (0.4 mL, 4.3 mmol) in methanol (10 mL) was heated to reflux and maintained overnight. The solvent was removed in vacuo to give a residue which was washed with 20% ethyl acetate in hexane to afford 2-methyl-1-[2-oxo-2-(tetrahydro-pyran-4-yl)-ethyl]-pyridinium bromide (0.75 g, 86%) as a semi-solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524705B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-203bea987b4746448a898a969cf61fa0 |
| 출처 메모 | uspto-grants-2013_09 |