Ethanol → Ethyl 1-methyl-1H-indole-6-carboxylate

HRID 378370

반응식

HRID 378370 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([OH:13])=[O:12])[CH:9]=2)[CH:4]=[CH:3]1.[CH2:14](O)[CH3:15]>C(Cl)Cl>[CH2:14]([O:12][C:11]([C:8]1[CH:9]=[C:10]2[C:5]([CH:4]=[CH:3][N:2]2[CH3:1])=[CH:6][CH:7]=1)=[O:13])[CH3:15]

참가 물질

4

반응물 2

HCID 702EthanolHCID 198192611-Methyl-1H-indole-6-carboxylic acid

생성물 1

HCID 53770857Ethyl 1-methyl-1H-indole-6-carboxylate수율 89%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 1.05 g (6.0 mmol) of 1-methyl-1H-indole-6-carboxylic acid in 15 mL of methylene chloride was added to a stirring solution of 1.905 g (10 mmole) of 1-ethyl-3-(3dimethyl-aminopropyl)carbodiimide hydrochloride, 1.20 g (10 mmole) of 4-dirmethylaminopyridine in 20 mL of methylene chloride at room temperature. Ethanol was added and the reaction stirred for 15 h. The reaction mixture was extracted with ethyl acetate, the organic phase was washed with brine and dried on anhydrous magnesium sulfate. Chrorriatographic purification of this material gave 1.08 g (89%) of 1-methyl-1H-indole-6-carboxylic acid ethyl ester as a pale yellow oil.

후처리

  1. extractionThe reaction mixture was extracted with ethyl acetate
  2. washthe organic phase was washed with brine
  3. dry with materialdried on anhydrous magnesium sulfate
  4. customChrorriatographic purification of this material

출처 및 근거

ORD 기록
ord-2d756c730e8646349705d48543bdfbb4
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06030994

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