2-Chloropropyldimethylamine → 1-(2-trifluoromethylbenzyl)-2-(3-methylphenyl)-6-[1-methyl-2-(N,N-dimethylamino)ethoxy]-benzimidazole

HRID 378415노트

반응식

HRID 378415 반응식
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:26]=[CH:25][CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[C:10]2[CH:11]=[C:12]([OH:15])[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=1.[CH3:29][CH:30](Cl)[CH2:31][N:32]([CH3:34])[CH3:33]>>[F:28][C:2]([F:1])([F:27])[C:3]1[CH:26]=[CH:25][CH:24]=[CH:23][C:4]=1[CH2:5][N:6]1[C:10]2[CH:11]=[C:12]([O:15][CH:30]([CH3:29])[CH2:31][N:32]([CH3:34])[CH3:33])[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=1

참가 물질

3

반응물 2

HCID 927382-ChloropropyldimethylamineHCID 193539881-(2-Trifluoromethylbenzyl)-2-(3-methylphenyl)-6-hydroxybenzimidazole

생성물 1

HCID 193539441-(2-trifluoromethylbenzyl)-2-(3-methylphenyl)-6-[1-methyl-2-(N,N-dimethylamino)ethoxy]-benzimidazole

실험 절차

The title compound was prepared essentially as described above except that the compound of Example 120 was reacted with 1-methyl-2-(N,N-dimethylamino)ethyl chloride, yielding the title product as an oil.

후처리

  1. customThe title compound was prepared essentially

출처 및 근거

ORD 기록
ord-93ef04e99a4f469b8e15ce27f0d53d45
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06030992

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