2,4,5-Trichlorobenzenesulfonyl chloride → 2,4,5-Trichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide

반응식

[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([Cl:17])=[CH:12][C:11]=1[S:18](Cl)(=[O:20])=[O:19]>>[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([Cl:17])=[CH:12][C:11]=1[S:18]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:20])=[O:19]

참가 물질

반응물 2

HCID 275752,4,5-Trichlorobenzenesulfonyl chloride

HCID 104875194-Bromo-3-methylisoxazol-5-amine

생성물 1

HCID 186172862,4,5-Trichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide수율 67%

실험 절차

2,4,5-Trichloro-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2,4,5-trichlorobenzenesulfonyl chloride according to the procedures described in Example 30. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 179-182° C., yield 67%.

후처리

customThe crude product was purified by recrystallization from ethyl acetate/hexanes
customto give a crystalline solid, m.p. 179-182° C., yield 67%

출처 및 근거

ORD 기록: ord-3e3c6d3cebdb48c893139c026fd35837
출처 데이터셋: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06030991

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