Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-Chlorophenoxy)acetic acid → 2-(4-chlorophenoxy)-N-[5-(imidazol-1-yl)pentyl]acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-Chlorophenoxy)acetic acid | HCID 26229 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 1H-Imidazole-1-pentanamine | HCID 7138434 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(4-chlorophenoxy)-N-[5-(imidazol-1-yl)pentyl]acetamide | HCID 18349771 | — |
반응 단계
1,1'-Carbonyldiimidazole (6.48 g) was added to a solution of 4-chlorophenoxyacetic acid (7.46 g) in THF (144 ml.) at ambient temperature. The mixture was stirred for 2 hours and then 1-(5-aminopentyl)imidazole (6.1 g) was added. The mixture was stirred at ambient temperature for 18 hours and then worked up as described in Example 9a to give an oil which was purified by flash chromatography on silica using ethyl acetate/methanol/triethylamine, 18:2:1 as the mobile phase to give 2-(4-chlorophenoxy)-N-[5-(imidazol-1-yl)pentyl]acetamide as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06031109 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-c3c03d208a5246ecb2715e5a5d03c9ef |
| 출처 메모 | uspto-grants-2000_02 |