4-Cyanobenzoyl chloride → HCID 54323930, 화합물

반응식

[NH2:1][CH2:2][CH2:3][C:4]1[N:5]=[CH:6][N:7]([CH2:9][CH2:10][CH2:11][NH:12][C:13]([CH2:22][CH3:23])([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:14][CH3:15])[CH:8]=1.[C:24]([C:26]1[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[CH:28][CH:27]=1)#[N:25]>>[C:24]([C:26]1[CH:34]=[CH:33][C:29]([C:30]([NH:1][CH2:2][CH2:3][C:4]2[N:5]=[CH:6][N:7]([CH2:9][CH2:10][CH2:11][NH:12][C:13]([CH2:22][CH3:23])([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][CH3:15])[CH:8]=2)=[O:31])=[CH:28][CH:27]=1)#[N:25]

참가 물질

반응물 2

HCID 801724-Cyanobenzoyl chloride

HCID 183495694-(2-Aminoethyl)-N-(1-ethyl-1-phenylpropyl)-1H-imidazole-1-propanamine

생성물 1

HCID 54323930HCID 54323930, 화합물

실험 절차

3-[4-(2-Aminoethyl)imidazol-1-yl]-N-(1-ethyl-1-phenylpropyl)propylamine (0.5 g) was reacted with 4-cyanobenzoyl chloride (0.27 g) in a similar manner to Example 55 to give 4-cyano-N-(2-{1-[3-(1-ethyl-1-phenylpropylamino)propyl]imidazol-4-yl}ethyl)benzamide, m.p. 107-109° C.

출처 및 근거

ORD 기록: ord-c81307826e8340f8b1b6fbe8c3eec568
출처 데이터셋: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06031109

반응 노트

불러오는 중…