Ethanol → Ethyl 2-methoxy-6-nitrophenylacetate

HRID 37869

반응식

HRID 37869 반응식
S(=O)(=O)(O)[OH:2].[CH3:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[C:9]=1[CH2:17][C:18]#N.[CH2:20]([OH:22])[CH3:21]>>[CH2:20]([O:22][C:18](=[O:2])[CH2:17][C:9]1[C:10]([N+:14]([O-:16])=[O:15])=[CH:11][CH:12]=[CH:13][C:8]=1[O:7][CH3:6])[CH3:21]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 5550182-(2-Methoxy-6-nitrophenyl)acetonitrile

생성물 1

HCID 58216762Ethyl 2-methoxy-6-nitrophenylacetate수율 72%

실험 절차

Sulfuric acid (1 mL) was slowly added to a solution of (2-methoxy-6-nitro-phenyl)-acetonitrile (200 mg, 1.04 mmol) in 95% ethanol (2 mL). The mixture was heated at reflux overnight then quenched into ice cold water and extracted with diethyl ether (10 mL). The organic phase was washed with water (2×10 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to afford (2-methoxy-6-nitro-phenyl)-acetic acid ethyl ester (180 mg, 72%).

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux overnight
  3. customthen quenched into ice cold water
  4. extractionextracted with diethyl ether (10 mL)
  5. washThe organic phase was washed with water (2×10 mL)
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-202240da0fa5439b9bc95d88814baa97
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524705B2

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