Ammonium Hydroxide → 4-Amino-3,5,6-trifluoro-2-cyanopyridine
반응식
[F:1][C:2]1[C:3]([C:11]#[N:12])=[N:4][C:5]([F:10])=[C:6]([F:9])[C:7]=1F.[OH-].[NH4+:14]>CN(C=O)C.O>[NH2:14][C:7]1[C:6]([F:9])=[C:5]([F:10])[N:4]=[C:3]([C:11]#[N:12])[C:2]=1[F:1]참가 물질
5
실험 절차
To a solution of 3,4,5,6-tetrafluoro-2-cyanopyridine in DMF (75 mL) at 0C was slowly added concentrated ammonium hydroxide (15 mL). The reaction was stirred and additional 15 min and the solution was diluted with water (150 mL). The solid was collected and air dried to give 4-amino-3,5,6-trifluoro-2-cyanopyridine (25.5 g, 0.16 mol, 92%); mp 291-30 C.
후처리
- customThe solid was collected
- customair dried
출처 및 근거
- ORD 기록
- ord-863ffce9f2b545329952788ae4bad168
- 출처 데이터셋
- uspto-grants-2001_10
- 특허 번호
- US06297197B1
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