Hydrazine → Pyrazine-2-Carboxylic Acid Hydrazide

HRID 378833

반응식

HRID 378833 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][NH2:12]>CO>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:11][NH2:12])=[O:9]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 72662Methyl pyrazinoate

생성물 1

HCID 258796Pyrazine-2-Carboxylic Acid Hydrazide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of the product from Example 1 step c) (22 g, 159 mmol) in methanol (250 ml) was slowly added hydrazine monhydrate (36.6 ml, 710 mmol). The reaction mixture was stirred for 1.5 h. The precipitate produced was filtered, washed with diethyl ether and dried in the oven at 80° C. to give the required product (30 g). 1H NMR (250 MHz, DMSO) δ 4.66 (2H, broad peak), 8.66 (1H, m), 8.84 (1H, d, J=2.5 Hz), 9.13 (1H, d, J=2.5 Hz), 10.15 (1H, broad peak); MS (ES+) m/e 139 [MH+].

후처리

  1. customThe precipitate produced
  2. filtrationwas filtered
  3. washwashed with diethyl ether
  4. customdried in the oven at 80° C.

출처 및 근거

ORD 기록
ord-8880dd93059d499192c4c6be784ff1e1
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297235B1

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