Oxalyl chloride → 4-Bromo-2-methylbenzoyl chloride

HRID 378894노트

반응식

HRID 378894 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([CH3:11])[CH:3]=1.C(Cl)(=O)C([Cl:15])=O>ClCCl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[C:4]([CH3:11])[CH:3]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 995704-Bromo-2-methylbenzoic acid

생성물 1

HCID 128464834-Bromo-2-methylbenzoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane촉매

실험 절차

A suspension of 4bromo-2-methylbenzoic acid (4.9 g, 22.8 mmol) in dichioromethane containing a few drops of N,N-dimethylformamde was treated dropwise under nitrogen with oxalyl chloride (2.4 mL, 27.5 mol). After gas evolution subsided, the reaction mixture was refluxed for an additional 15 minutes and then evaporated to dryness in vacuo to provide the crude 4-bromo-2-methylbenzoyl chloride.

후처리

  1. temperaturethe reaction mixture was refluxed for an additional 15 minutes
  2. customevaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-b5ef46d355a645e1ae379e14e4216879
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297234B1

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