4-Phenylpiperidinium chloride → HCID 444789, 화합물

반응식

F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]([CH2:16][C:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)[C:13]([OH:15])=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl.[C:27]1([CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[NH:19]1[C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17]([CH2:16][C@H:12]([NH:11][S:8]([C:5]2[CH:6]=[CH:7][C:2]([N:36]3[CH2:37][CH2:38][CH:33]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH2:34][CH2:35]3)=[CH:3][CH:4]=2)(=[O:10])=[O:9])[C:13]([OH:15])=[O:14])=[CH:18]1

참가 물질

반응물 2

HCID 825094-Phenylpiperidinium chloride

HCID 1091373L-Tryptophan, N-((4-fluorophenyl)sulfonyl)-

생성물 1

HCID 444789HCID 444789, 화합물

실험 절차

In a manner similar to Example 3(b), (S)-2-(4-fluoro-benzenesulfonylamino)-3-(1H-Indol-3-yl)-propionic acid was condensed with 4-phenyl-piperidine hydrochloride to give the title compound, mp=103-107° C.

출처 및 근거

ORD 기록: ord-a8949ac992f4445aa75acda3c08117dd
출처 데이터셋: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06297247B1

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