Dimethylformamide diethylacetal → Ethyl 3-(dimethylamino)-2-(5-bromopyridin-3-yl)acrylate
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[N:6][CH:7]=1.C(O[CH:17](OCC)[N:18]([CH3:20])[CH3:19])C>>[CH3:17][N:18]([CH3:20])[CH:19]=[C:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[C:9]([O:11][CH2:12][CH3:13])=[O:10]참가 물질
3
실험 절차
5.1 g (20.9 mmol) of the compound from Example 10A are stirred in 7.2 ml (6.2 g, 41.8 mmol) of dimethylformamide diethyl acetal at a bath temperature of 100° C. for 16 h. After cooling, the mixture is concentrated under reduced pressure, the residue is stirred in diisopropyl ether, and the solid is filtered off and finally washed with diisopropyl ether. The crude product is dried under reduced pressure for 16 h.
후처리
- temperatureAfter cooling
- concentrationthe mixture is concentrated under reduced pressure
- filtrationthe solid is filtered off
- washfinally washed with diisopropyl ether
- dry with materialThe crude product is dried under reduced pressure for 16 h.
출처 및 근거
- ORD 기록
- ord-fdad1c24727e4b5282819bcce813ea66
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524699B2
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