Water → 1-Methylsulfonyloxy-5-phenylpentane

HRID 378973노트

반응식

HRID 378973 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22].O>C(Cl)Cl>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 615235-Phenyl-1-pentanol

생성물 1

HCID 116301071-Methylsulfonyloxy-5-phenylpentane수율 100.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

5-Phenyl-pentanol (40 g, 244 mmoles) in methylene chloride (80 ml) at 0° C. was added with triethylamine (39 ml, 28.34 g, 280 mmoles) and a solution of methyl-sulfonyl chloride (20.7 ml, 30.69 g, 268 mmoles) in methylene chloride (40 ml). The temperature was left to rise to the room value, then the mixture was poured into water and the organic phase was isolated, washed with water, anhydrified and concentrated to give 59.49 g of the title product (yield: 99%).

후처리

  1. waitThe temperature was left
  2. customthe organic phase was isolated
  3. washwashed with water, anhydrified
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-23c3cb3c1e2c4f0389ecf98416913ab2
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297257B1

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