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Dimethylformamide → HCID 178451357, 화합물

HRID 378988
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HRID 378988 반응식
[NH:1]([C:5]1[S:6][C:7]([C:11]([OH:13])=O)=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3].CN(C=O)C.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.Cl.[NH2:44][CH2:45][CH2:46][CH2:47][O:48][CH2:49][C:50]([O:52][CH2:53][CH2:54][CH2:55][CH3:56])=[O:51]>C(OCC)(=O)C>[NH:1]([C:5]1[S:6][C:7]([C:11]([NH:44][CH2:45][CH2:46][CH2:47][O:48][CH2:49][C:50]([O:52][CH2:53][CH2:54][CH2:55][CH3:56])=[O:51])=[O:13])=[C:8]([CH3:10])[N:9]=1)[C:2]([NH2:4])=[NH:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 86757461Butyl (3-amino-propoxy)-acetate hydrochlorideHCID 178433209HCID 178433209, 화합물

생성물 1

HCID 178451357HCID 178451357, 화합물수율 50%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

175 mg of 2-guanidino-4-methyl-thiazole-5-carboxylic acid, 2.6 ml of DMF, 0.29 ml of N-MM and 332 mg of HBTU are stirred at room temperature (RT) for one hour, treated with 197 mg of butyl (3-amino-propoxy)-acetate hydrochloride and stirred at RT for a further 18 hrs. For the working up, the mixture is diluted with ethyl acetate, washed with dilute sodium carbonate solution, dilute sodium chloride solution and saturated sodium chloride solution, dried and evaporated in a vacuum. Chromatography on silica gel with methylene chloride-alcohol gives 162 mg of butyl {3-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-propoxy}-acetate, mass spectroscopy (MS): 372 (M+H)+.

후처리

  1. washwashed with dilute sodium carbonate solution, dilute sodium chloride solution and saturated sodium chloride solution
  2. customdried
  3. customevaporated in a vacuum

출처 및 근거

ORD 기록
ord-687b268787bd424297635cf23ba3c159
출처 데이터셋
uspto-grants-2001_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06297266B1

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