Imidazole → 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

HRID 379031노트

반응식

HRID 379031 반응식
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([OH:11])[CH:4]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>CN(C=O)C>[OH:11][C:5]1[CH:4]=[C:3]([CH2:2][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 216969934-(Bromomethyl)-2-hydroxybenzonitrile

생성물 1

HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-bromomethyl-2-hydroxy-benzonitrile (0.22 g, 1.05 mmol) and imidazole (0.36 g, 5.23 mmol) were dissolved in DMF (10 mL) with stirring at ambient temperature. After stirring for 18 h, the reaction mixture was concentrated in vacuo and purified by silica gel chromatography eluting with 2% CH3OH/CH2C12 to 5% CH3OH/CH2Cl2 to give the title compound.

후처리

  1. stirringAfter stirring for 18 h
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. custompurified by silica gel chromatography
  4. washeluting with 2% CH3OH/CH2C12 to 5% CH3OH/CH2Cl2

출처 및 근거

ORD 기록
ord-b0d36694988949c584188e150db9557d
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297239B1

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