Triethylamine → HCID 53921157, 화합물

HRID 379038

반응식

HRID 379038 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([OH:7])=[O:6].[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1B(O)O.[CH2:25](N(CC)CC)C>C(Cl)Cl>[CH3:25][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([I:11])=[C:2]([O:1][C:13]2[CH:14]=[CH:15][C:16]3[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:12]=2)[CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 7368543-Hydroxy-4-iodobenzoic acidHCID 2734375(Naphthalen-2-yl)boronic acid

생성물 1

HCID 53921157HCID 53921157, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 3-hydroxy-4-iodo-benzoic acid acid methyl ester (0.505 g, 1.82 mmol), cupric acetate (0.330 g, 1.82 mmol), 2-naphthylboronic acid (0.625 g, 3.63 mmol) and powdered 4A molecular sieves (0.3 g) in CH2Cl2 (21 mL) was treated with triethylamine (1.27 mL, 9.08 mmol) and stirred at ambient temperature for 18 hr. The reaction mixture was filtered through celite, concentrated to dryness and chromatographed (SiO2, 5-40% EtOAc: hexane) to give the title compound. FAB mass spectrum (M+1) 405.

후처리

  1. filtrationThe reaction mixture was filtered through celite,
  2. concentrationconcentrated to dryness
  3. customchromatographed (SiO2, 5-40% EtOAc: hexane)

출처 및 근거

ORD 기록
ord-4c3bea01e7014b94b4af9526bf27f2c4
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297239B1

연결된 노트

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