Acetonitrile → 2-Fluoro-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile

HRID 379067노트

반응식

HRID 379067 반응식
[F:1][C:2]1[CH:9]=[C:8]([CH:10]([OH:17])[C:11]2[N:12]([CH3:16])[CH:13]=[N:14][CH:15]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].CC#N>C(Cl)Cl.O=[Mn]=O>[F:1][C:2]1[CH:9]=[C:8]([C:10]([C:11]2[N:12]([CH3:16])[CH:13]=[N:14][CH:15]=2)=[O:17])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

5

반응물 2

HCID 6342AcetonitrileHCID 185332012-Fluoro-4-(hydroxy(1-methyl-1h-imidazol-5-yl)methyl)benzonitrile

생성물 1

HCID 185332052-Fluoro-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

2-Fluoro-4-[hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile (as described in Example 22, Step E) (0.655 g, 2.83 mmol) and MnO2 (1.23 g, 14.2 mmol) were stirred in CH2Cl2 (50 mL) and CH3CN (5 mL) for 72 h. The solution was filtered and concentrated to yield the title compound.

후처리

  1. filtrationThe solution was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-19d2e1097f044f92a6d58bf07bdeb4a2
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06297239B1

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