참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | o-Iodoanisole | HCID 68257 | — |
| 반응물 | HCID 178516071 | HCID 178516071 | — |
| 촉매 | Copper | HCID 23978 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2(1H)-Pyridinone, 1-(2-methoxyphenyl)- | HCID 12191389 | — |
반응 단계
2-Iodoanisole (1.30 mL, 0.01 mol), 2-hydroxypyridine (0.95 g, 0.01 mol), anhydrous K2CO3 (2.76 g, 0.02 mol) and copper powder (0.0636 g, 0.001 mol) were combined and heated at 200° C. for 2 hr. The reaction mixture was cooled, EtOAc added, and filtered. The filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine, and dried (Na2SO4). Filtration and concentration gave the title compound after chromatography (silica gel, 2% CH3OH, CH2Cl2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06297239B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_10 |
|---|
| ORD ID | ord-4c3a55ba796041aab00b78a70ae21ba3 |
|---|
| 출처 메모 | uspto-grants-2001_10 |
|---|
